Five Guys is a high-protein opportunity hiding inside a high-calorie trap. The burgers themselves made from fresh, never-frozen beef with no fillers – are actually one of the cleanest protein sources at any fast-food chain. The problem is portion size: a regular Five Guys burger is a double patty, and the fry portions are famously enormous. For GLP-1 users, the solution is simple: order the Little Burger in a bowl or lettuce wrap, load up on free toppings like grilled mushrooms and onions, skip the fries entirely, and you’ve got a ~300 calorie, 26g protein meal that actually satisfies.
High-Protein Options
These meals provide 25g+ protein per serving
Hamburger (lettuce wrap)
Two beef patties wrapped in lettuce with veggie toppings
Little Cheeseburger (no bun)
Single beef patty with American cheese and fresh toppings — bunless
Bacon Burger (lettuce wrap)
Two beef patties, bacon, wrapped in lettuce
28g protein
GLP-1 Friendly Choices
Easy-to-digest meals that won’t cause discomfort
Little Hamburger Bowl
One patty in bowl with lettuce, tomatoes, grilled onions, mushrooms
Veggie Sandwich (add beef patty)
Grilled veggies with one beef patty added for protein
22g protein
Grilled Cheese (no bread, protein added)
Ask for a patty with grilled onions, mushrooms, and jalapenos in a bowl — low carb
20g protein
Tips for Ordering Five Guys GLP-1 Meals
Five Guys GLP-1 meals work best when you order the Little size rather than the regular — a regular Five Guys burger is actually a double patty, which is far more than most GLP-1 users need in one sitting. Always ask for your burger in a lettuce wrap or a bowl, as Five Guys is very accommodating with custom orders. Load up on free toppings like grilled mushrooms, grilled onions, jalapenos, and fresh vegetables to add volume and flavor without adding meaningful calories. Skip the Cajun fries entirely — even a small portion is extremely calorie-dense and high in sodium, which worsens bloating on GLP-1 medications like Ozempic and Wegovy.
What to Avoid at Five Guys on GLP-1
Skip the regular and large burgers with buns, the milkshakes, and all fry sizes. Five Guys portions are famously oversized — a regular burger is two patties and the fry portions are enormous. These Five Guys meals are among the highest-calorie options at any fast-food chain and are particularly difficult to digest on GLP-1 medications. The milkshakes can exceed 1,000 calories and 100g of sugar in a single cup.
Best Low-Calorie Five Guys Options on GLP-1
The Little Burger bunless in a bowl with lettuce, tomato, onion, and mustard is the best low-calorie Five Guys GLP-1 meal — around 300 calories with 26g of protein. Adding grilled mushrooms and onions brings extra flavor for almost zero additional calories.
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